Tacrolimus Pharmacokinetics in Sinclair Nanopigs: Comparison of Traditional Sampling and Automated Dried Blood Spot Collection
Downsized Sinclair vs. Göttingen Minipigs Similarities and Differences of Toxicological Reference Range Data in Preclinical Safety Studies (Altasciences)
Comparative Photomicrographic Examination of Integument from Eight Species of Mammals Including two Lineages of Research Miniswine
Skin is the largest organ in the body. Animals have skin which is generally similar to human skin, however, species specific anatomical and biochemical differences exist. The integument of animal models may vary in skin surface topography, overall thickness and thickness of specific layers, stratum corneum, epidermis, dermis density and collagen content, regional blood flow, pelage (hair count), hair follicle size or density, and sub-dermal characteristics. Determination of which animal model most closely matches the skin of humans is important for translational dermal research.
Size Matters: The Sinclair Nanopig® as a Translational Non-Rodent Model in Preclinical Research
Experimental Induction of Allergic Contact Dermatitis in Sinclair, Hanford, and Yucatan Minipigs
Animal Models in Toxicologic Research: Pig
Chapter 20, In Haschek and Rousseaux's Handbook of Toxicologic Pathology (Fourth Edition)
A Changing Paradigm for Non-Rodent Species in Nonclinical Safety Studies: The miniature swine as an option in small and large molecule studies
Comparison of human, porcine & rodent wound healing with new miniature swine study data
This study compares wound healing characteristics across humans, traditional porcine models, rodent models, and new miniature swine, highlighting that pig skin more closely mirrors human skin in structure and healing by re-epithelialization rather than contraction. It also presents data showing that re-epithelialization rates in miniature swine vary with age and diabetic status, and concludes that miniature swine are a predictive and useful model for human wound healing research.
No results found.