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Pharmacokinetic Evaluation of Colchicine and Hydrochlorothiazide in Sinclair and Gottingen Miniature Swine

The objective of this study was to determine and compare plasma pharmacokinetic profiles of two compounds with very different elimination pathways, colchicine and hydrochlorothiazide, in Sinclair and Gottingen minipig. Hydrochlorothiazide not metabolized, mostly excreted in urine.

Minipig Model of Atopic Dermatitis: Assessment of In Vivo & In Vitro Activity of Recombinant Porcine Interleukin-4 & Interleukin-13

Assessment of recombinant IL-4 and IL-13 in Hanford minipigs demonstrated IL-4-driven immune activity and mild dermal inflammation, informing further development of a minipig model of atopic dermatitis.
No results found.