Characterization of Normal Skin Thickness For Various Body Regions, Ages and Genders of Yucatan Miniature Swine
This study measured and compared the histologic skin thickness of Yucatan miniature swine across different body regions, age groups, and genders to provide detailed baseline data relevant for biomedical research, especially for studies involving drug absorption, wound healing, or dermatology. The results show that skin thickness varies by body site, age, and gender, and that overall Yucatan skin thickness closely resembles human skin, with dermis being the largest component of total skin thickness.
Tacrolimus Pharmacokinetics in Sinclair Nanopigs: Comparison of Traditional Sampling and Automated Dried Blood Spot Collection
Comparison of automated dried blood spot and traditional whole-blood sampling produced comparable tacrolimus pharmacokinetic profiles, supporting the Sinclair Nanopig and low-volume automated sampling for PK studies.
Downsized Sinclair vs. Göttingen Minipigs Similarities and Differences of Toxicological Reference Range Data in Preclinical Safety Studies (Altasciences)
Comparison of toxicological reference data in downsized Sinclair Nanopigs and Göttingen minipigs found broadly similar clinical pathology, organ-weight, and background histopathology profiles, with only minor biologically significant differences.
Comparative Photomicrographic Examination of Integument from Eight Species of Mammals Including two Lineages of Research Miniswine
Skin is the largest organ in the body. Animals have skin which is generally similar to human skin, however, species specific anatomical and biochemical differences exist. The integument of animal models may vary in skin surface topography, overall thickness and thickness of specific layers, stratum corneum, epidermis, dermis density and collagen content, regional blood flow, pelage (hair count), hair follicle size or density, and sub-dermal characteristics. Determination of which animal model most closely matches the skin of humans is important for translational dermal research.
Size Matters: The Sinclair Nanopig® as a Translational Non-Rodent Model in Preclinical Research
The Altascientist Issue No. 47 - Take a closer look at what makes the Sinclair Nanopig® a scientifically appropriate and cost-effective non-rodent species,
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