Current Applications of Minipigs in Regulatory Safety Assessment
Discussion of how minipigs are used in regulatory safety studies including cardiotoxicity, neurotoxicity, and organ toxicity models.
Microbiome and Inflammasome Alterations Found During Radiation Dose Finding in a Sinclair Minipig Model of Gastrointestinal Acute Radiation Syndrome
We aimed to determine the radiation dose requirements for creating GI-ARS in the Sinclair minipig.
Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments
A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the preclinical safety pharmacology testing guidelines.
Background Pathological Changes in Minipigs: A Comparison of the Incidence and Nature among Different Breeds and Populations of Minipigs
This article is a collaborative effort between multiple organizations to define and document lesions found in the common breeds of minipigs used for toxicological risk assessment in North America (NA) and the European Union (EU).
Surgical & Non-Surgical Drug Delivery Methods in Miniature Swine
Overview of administration techniques including catheterization, oral dosing, and implantable delivery systems.
Behavior Enhancement System Bulletin
Description of enrichment systems designed to encourage natural behavior and reduce stress in research swine.
Heart Failure Models in Swine
Description of experimental heart failure models used to evaluate therapies and disease mechanisms.
Bone Marrow Access in Swine
Anatomical landmarks and procedural methods for bone marrow collection or administration via intraosseous access.
No results found.