Pig Models for Gene Therapy: Prevalence of Adeno-associated Virus Neutralizing Antibodies in the Yucatan Miniature Swine and the Sinclair Nanopig
Gene therapy is a rapidly advancing field, with large animal models like non-human primates and miniature pigs playing a key role in evaluating the safety and effectiveness of AAV-based treatments due to their biological similarity to humans. This study focuses on measuring neutralizing antibodies to various AAV serotypes in different miniature swine cohorts, addressing a major limitation in translational research.
Anethesia and Analgesia in Swine
Anesthesia and analgesia is frequently required for swine in research due to the nature of the invasive procedures that are performed. Their use as preclinical models (translational research) frequently involves surgical implantation of devices, major invasive surgery and creation of disease conditions, such as heart failure.
Pharmacokinetic Evaluation of Colchicine and Hydrochlorothiazide in Sinclair and Gottingen Miniature Swine
The objective of this study was to determine and compare plasma pharmacokinetic profiles of two compounds with very different elimination pathways, colchicine and hydrochlorothiazide, in Sinclair and Gottingen minipig. Hydrochlorothiazide not metabolized, mostly excreted in urine.
Behavioral Enhancement System™
More information is available by request on our Behavior Enhancement System Application Bulletin.
Minipig Model of Atopic Dermatitis: Assessment of In Vivo & In Vitro Activity of Recombinant Porcine Interleukin-4 & Interleukin-13
Identification of immunophenotyping biomarkers & characterization of peripheral blood lymphocytes populations distribution in minipigs
Characterization of Normal Skin Thickness For Various Body Regions, Ages and Genders of Yucatan Miniature Swine
This study measured and compared the histologic skin thickness of Yucatan miniature swine across different body regions, age groups, and genders to provide detailed baseline data relevant for biomedical research, especially for studies involving drug absorption, wound healing, or dermatology. The results show that skin thickness varies by body site, age, and gender, and that overall Yucatan skin thickness closely resembles human skin, with dermis being the largest component of total skin thickness.
Tacrolimus Pharmacokinetics in Sinclair Nanopigs: Comparison of Traditional Sampling and Automated Dried Blood Spot Collection
No results found.