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Introducing the Sinclair Nanopig model: Preliminary genomic, proteomic, and hepatic CYP450 characterization for (bio)pharmaceutical safety assessment

The Nanopig model is an emerging non-rodent platform for (bio)pharmaceutical safety assessment, with potential ...

White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development

Development of a miniature-pig model of adolescent brain development for neuroimaging and neurophysiological ...

Duraplasty in Traumatic Thoracic Spinal Cord Injury: Impact on Spinal Cord Hemodynamics, Tissue Metabolism, Histology, and Behavioral Recovery Using a Porcine Mod

A porcine model of tramatic spinal cord injury (SCI) developed in Yucatan pigs was used to evaluate the impact of ...

Blocking RAGE improves wound healing in diabetic pigs

We proposed that administering an antibody that blocks RAGE will hasten the healing of dorsal wounds in diabetic ...

Microbiome and Inflammasome Alterations Found During Radiation Dose Finding in a Sinclair Minipig Model of Gastrointestinal Acute Radiation Syndrome

We aimed to determine the radiation dose requirements for creating GI-ARS in the Sinclair minipig.

Development of a Functional Observational Battery in the Minipig for Regulatory Neurotoxicity Assessments

A functional observational battery (FOB) is recommended as the first-tier neurotoxicity screening in the ...

Background Pathological Changes in Minipigs: A Comparison of the Incidence and Nature among Different Breeds and Populations of Minipigs

This article is a collaborative effort between multiple organizations to define and document lesions found in the ...

The Miniature Swine as a Model in Experimental and Translational Medicine

Translational preclinical swine study data presented here support the current understanding that miniature swine ...

Preparation of Swine for the Laboratory

It is important to acclimate the animals to the facility and to personnel before they are placed on chronic ...

A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model

We used a porcine model to evaluate the impact of burn, radiation, and CI on the gut microbiota and liver transcriptomics
No results found.