An assessment of pharmacokinetic, metabolic, and hormonal differences in minipig strains
This study compared the pharmacokinetics, metabolism, and stress hormone responses of Hanford, Göttingen, Yucatan, and Sinclair minipigs after oral and IV dosing of a chiral test compound and found only minor (less than two-fold) differences in clearance, volume, bioavailability, and chiral inversion across strains. However, cortisol responses to a short-term stressor were lowest in the Sinclair minipig, suggesting that while PK differences are minimal, strain selection may be important depending on whether a study is sensitive to stress effects, particularly in chronic versus acute designs.
Swine in the Laboratory: Surgery, Anesthesia, and Experimental Techniques, 3rd Edition
For two decades, Swine in the Laboratory: Surgery, Anesthesia, and Experimental Techniques has been the most respected practical technical guide for medical and veterinary researchers using swine as experimental animals. Extensively updated and expanded since the publication of the second edition in 2007 and now sponsored by the American College of Laboratory Animal Medicine (ACLAM), it continues to be the most authoritative source of scientific and technical information on the use of domestic and miniature swine in research.
Genetic Selection and Nutritional Management for a Downsized Sinclair Miniature Swine
The objective of this study was to utilize genomic selection, phenotype, body weight, and nutritional management to reduce the total body mass in adult Sinclair S-1 MS.
Comparison of Cardiovascular and Respiratory Parameters in Three Strains of Research Pigs; Sinclair Nanopig™, Göttingen Minipig®, and Yucatan™ Miniature Swine
Comparison of cardiovascular and respiratory parameters across Sinclair Nanopig, Göttingen, and Yucatan minipigs supports the Sinclair Nanopig as a suitable model for safety pharmacology studies.
Anatomy and Histology of the Pig: A Concise Full-Color Atlas
This comprehensive anatomy and histology book is the first guide specific to the pig since 1982. The high-quality, detailed full-color illustrations are accompanied by written material specific to each porcine anatomic section, with English-labeled terms for the various anatomic structures. The book covers all the major areas of interest in swine, including cardiovascular, digestive, neurologic, and thoracic structures. Differences between domestic and miniature pigs are discussed and a full-color histology section concludes the book.
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