Determinant of Ischemic Wound Healing in Diabetes- A Bipediclle flap wound model in diabetic yucatan miniature swine
Development of a bipedicle flap wound model in diabetic Yucatan miniature swine demonstrated delayed ischemic wound healing and established a clinically relevant model for diabetic wound-healing research.
Acute dermal irritation response in white Sinclair, Hanford, and Göttingen Minipigs
The study evaluated acute dermal irritation in White Sinclair and Hanford miniature swine by applying known human skin irritants topically and scoring erythema and edema over time to assess how porcine skin reacts to irritants. It shows that miniature swine develop measurable skin irritation responses using a modified Draize scoring system, supporting their use as a model for dermal irritation testing in preclinical research
Pharmacokinetics of intravenous and oral metformin and r,s verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs
Comparison of metformin and verapamil pharmacokinetics across Sinclair, Yucatan, Hanford, and Göttingen minipigs identified lineage-specific differences in drug clearance relevant to model selection.
Miniature Swine Breeds in Toxicology and Drug Safety Assessments: What to Expect during Clinical and Pathology Evaluations
The use of miniature swine as a nonrodent species in safety assessment has continued to expand for over a decade, and they are becoming routinely used in toxicology and in pharmacology as well as a model for human diseases.
Differential Cardiovascular Physiology and Pathology in Selected Lineages of Miniature Swine and Comparison to Human
Comparison of cardiovascular physiology and pathology in Sinclair, Yucatan, and Hanford miniature swine highlights their similarities to humans and lineage-specific differences relevant to model selection.
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